A Brief Introduction to Dosing and Administration

Dosing GHRPs

The saturation dose for most studies about the GHRPs (GHRP-6, GHRP-2, Ipamorelin & Hexarelin) is understood to be either 100mcg or 1mcg/kg.

What this means is always that 100mcg will saturate the receptors fully, however, if you set another 100mcg compared to that dose only 50% of the portion will likely be effective. In the event you add a different 100mcg fot it dose just about 25% will probably be effective. The final 100mcg might include a little something to GH release but that's it.

So 100mcg is the saturation dose and you can increase the around 300 to 400mcg and acquire more effect.

A 500mcg dose are not far better then the 400mcg, perhaps even if it's just more potent then 300mcg.

Any additional troubles are desensitization & cortisol/prolactin side-effects.

cjc-1293 is around as efficacious as GHRP-6 in causing GH release but even at higher dose (above 100mcg) this doesn't create prolactin or cortisol.

GHRP-6 with the saturation dose 100mcg will not really increase prolactin & cortisol but may do this slightly at higher doses. This rise continues to be from the normal range.

GHRP-2 is a bit more efficacious then GHRP-6 at causing GH release but in the saturation dose or more may make a slight to moderate rise in prolactin & cortisol. This rise continues to be from the normal range although doses of 200 - 400mcg might create it the top end from the normal range.

Hexarelin is easily the most efficacious of all the GHRPs at causing more GH release. But it really gets the highest potential to also increase cortisol & prolactin. This rise will occur even at the 100mcg saturation dose. This rise will attain the higher numbers of what is defined as normal.

Desensitization

GHRP-6 works extremely well at saturation dose (100mcg) 3 to 4 times per day without chance of desensitization.

GHRP-2 probably at saturation dose repeatedly a day will not bring about desensitization.

Hexarelin may bring about desensitization in a long-term study the pituitary recovered its sensitivity so that there is not long-term loss of sensitivity at saturation dose. However dosing Hexarelin even at 100mcg 3 times a day will probably lead to some down regulation within Two weeks. If desensitization would ever occur for almost any of those GHRPs simply stopping use stay will remedy this effect.

Chronic usage of GHRP-6 at 100mcg dosed several times a day every single day will not likely cause pituitary problems, nor significant prolactin or cortisol problems, nor desensitize.

GHRH

Now Sermorelin, GHRH (1-44) and GRF(1-29) each is basically GHRH and have a short half-life in plasma as a result of quick cleavage relating to the 2nd & 3rd amino. This really is no worry naturally as this hormone is secreted through the hypothalamus and travels ten or twenty yards for the underlying anterior pituitary and isn't really at the mercy of enzymatic cleavage. The making in the hypothalamus and binding to somatotrophs (pituitary cells) happens quickly.

However when injected in the body it has to circulate before finding its approach to the pituitary and so within 3 minutes it is already being degraded.

For this reason GHRH from the above forms must be dosed high to acquire an effect.

GHRH analogs

All GHRH analogs swap Alanine at the 2nd position for D-Alanine making the peptide resistant against quick cleavage at that position. Therefore analogs may well be more effective when injected at smaller dosing.

The analog tetra or 4 substituted GRF(1-29) sometimes called CJC w/o the DAC or known as by me as modified GRF(1-29) has other amino modifications. These are a glutamine (Gln or Q) in the 8-position, alanine (Ala or possibly a) with the 15-position, plus a leucine (Leu or L) in the 27-position.

The alanine at the 8th position enhances bioavailability nevertheless the other two amino substitutions are designed to boost the manufacturing process (i.e. create manufacturing stability).

For usage in vivo, in humans, the GHRH analog referred to as CJC w/o the DAC or tetra (4) substituted GRF(1-29) or modified GRF(1-29) is a very effective peptide which has a half-life probably 30+ minutes.

That's of sufficient length being completely effective.

The saturation dose is also understood to be 100mcg.

Problem w/ Using any GHRH alone

The problem with utilizing a GHRH even the stronger analogs is because are only noteworthy when somatostatin is low (the GH inhibiting hormone). When you unluckily administer in the trough (or every time a GH pulse is not natural) you will add little or no GH release. If yo happen to luckily administer after a rising wave or GH pulse (somatostatin will not be active now) you will help to increase GH release.

Solution is GHRP + GHRH analog

The perfect solution is is simple and highly effective. You administer a GHRH analog having a GHRP. The GHRP creates a pulse of GH. It can this through several mechanisms. One mechanism is the reduction of somatostatin release through the hypothalamus, these guys a rebate of somatostatin influence at the pituitary, one more is increased launch of GHRH in the brain lastly GHRPs act on a single pituitary cells (somatotrophs) similar to GHRHs but utilize a different mechanism to raise cAMP formation which will further cause GH release from somatotroph stores.

GHRH also has a method of reciprocally reinforcing GHRPs action.

The result is a synergistic GH release.

The GH just isn't additive it can be synergistic. By that I mean:

If GHRH on its own can cause a GH release worth 2 and GHRP itself can cause a GH release worth 5

Together the GH is not 7 (5+2) it happens to express 16!

A solid protocol

A solid protocol should be to use a GHRP + a GHRH analog pre-bed (to compliment the nightime pulse) and once or twice the whole day.

For anti-aging, deep restful restorative sleep, the once through the night dosing is perhaps all you need. For an adult aged 40+ it is enough to restore GH to youthful levels.

Nevertheless for bodybuilding or fatloss or injury repair multiple dosings may be effective.

The GHRH analog can be used at 100mcg so that as high as you would like effortlessly.

The GHRP-6 can always be utilized at 100mcg w/o problems but a dose of 200mcg is going to be fine too.

Again desensitization is something to maintain an eye on particularly using the highest doses of GHRP-2 and all sorts of doses of Hexarelin.

So 100 - 200mcg of GHRP-6 + 100 - 500mcg+ of your GHRH analog taken together will probably be effective. This might be dosed repeatedly every day to get highly effective.

A solid approach is much more conservative at 100mcg of GHRP-6 + 100mcg of the GHRH analog dosed either once, twice, 3 to 4 times each day. When dosing multiple times each day no less than Three hours should separate the administrations.

The difference is once daily dosing pre-bed will offer a tender restorative quantity of GH while multiple dosing or higher levels will give higher GH & IGF-1 levels when along with diet & exercise will bring about muscle gain & fatloss.

Dose w/o food

Administration should ideally be practiced on either a clear chair stomach or with only protein from the stomach. Fats & carbs blunt GH release. So administer the peptides and wait about 20 mins (forget about then 30 but truth be told then Quarter-hour) you can eat. AT that point the GH pulse has about hit the peak and you may eat what you would like.

For more information about GW1615 visit our website.