Ipamorelin results

Dosing GHRPs

The saturation dose in most studies about the GHRPs (GHRP-6, GHRP-2, Ipamorelin & Hexarelin) is understood to be either 100mcg or 1mcg/kg.

What which means is 100mcg will saturate the receptors fully, but if you set another 100mcg to that dose only 50% of these portion will likely be effective. In case you add one more 100mcg to that dose approximately 25% will likely be effective. The final 100mcg might add a little something to GH release but that's it.

So 100mcg may be the saturation dose and you can combine approximately 300 to 400mcg and have a bit more effect.

A 500mcg dose will not be far better then a 400mcg, perhaps not more effective then 300mcg.

The additional complaints are desensitization & cortisol/prolactin side-effects.

cjc-1293 is about as efficacious as GHRP-6 in causing GH release but even at higher dose (above 100mcg) it does not create prolactin or cortisol.

GHRP-6 at the saturation dose 100mcg doesn't really increase prolactin & cortisol but may do this slightly at higher doses. This rise continues to be from the normal range.

GHRP-2 might be a more efficacious then GHRP-6 at causing GH release but with the saturation dose or more may create a slight to moderate increase in prolactin & cortisol. This rise continues to be within the normal range although doses of 200 - 400mcg may make it the high end in the normal range.

Hexarelin is the most efficacious of all of the GHRPs at causing a rise in GH release. Nevertheless it has got the highest potential to can also increase cortisol & prolactin. This rise will occur even with the 100mcg saturation dose. This rise will achieve the higher amounts of what's defined as normal.

Desensitization

GHRP-6 may be used at saturation dose (100mcg) 3 to 4 times every day without risk of desensitization.

GHRP-2 probably at saturation dose several times each day will not likely cause desensitization.

Hexarelin is shown to bring about desensitization but also in a long-term study the pituitary recovered its sensitivity to ensure there were not long-term loss in sensitivity at saturation dose. However dosing Hexarelin even at 100mcg three times every day will likely lead to some down regulation within 14 days. If desensitization would ever occur for almost any of these GHRPs simply stopping use for several days will remedy this effect.

Chronic use of GHRP-6 at 100mcg dosed many times every day daily won't cause pituitary problems, nor significant prolactin or cortisol problems, nor desensitize.

GHRH

Now Sermorelin, GHRH (1-44) and GRF(1-29) each is basically GHRH where you can short half-life in plasma as a consequence of quick cleavage involving the 2nd & 3rd protein. This really is no worry naturally as this hormone is secreted from your hypothalamus and travels ten or twenty yards towards the underlying anterior pituitary and isn't really at the mercy of enzymatic cleavage. The discharge from the hypothalamus and binding to somatotrophs (pituitary cells) happens quickly.

But once injected in to the body it requires to circulate before finding its approach to the pituitary therefore within 3 minutes it really is already being degraded.

For this reason GHRH from the above forms have to be dosed high to obtain an effect.

GHRH analogs

All GHRH analogs swap Alanine in the 2nd position for D-Alanine helping to make the peptide proof against quick cleavage during this position. This means analogs is often more effective when injected at smaller dosing.

The analog tetra or 4 substituted GRF(1-29) sometimes called CJC w/o the DAC or known by me as modified GRF(1-29) has other amino acid modifications. They're a glutamine (Gln or Q) at the 8-position, alanine (Ala or perhaps a) with the 15-position, as well as a leucine (Leu or L) on the 27-position.

The alanine in the 8th position enhances bioavailability but the other two amino substitutions are designed to increase the manufacturing process (i.e. create manufacturing stability).

For usage in vivo, in humans, the GHRH analog known as CJC w/o the DAC or tetra (4) substituted GRF(1-29) or modified GRF(1-29) is definitely a effective peptide having a half-life probably 30+ minutes.

Which is long enough to get completely effective.

The saturation dose can also be looked as 100mcg.

Problem w/ Using any GHRH alone

The issue with using a GHRH even stronger analogs is because they are simply successful when somatostatin is low (the GH inhibiting hormone). When you unluckily administer in a trough (or every time a GH pulse just isn't natural) you are going to add hardly any GH release. If you luckily administer throughout a rising wave or GH pulse (somatostatin are not active at this point) you may increase GH release.

Solution is GHRP + GHRH analog

The solution is simple and highly effective. You administer a GHRH analog using a GHRP. The GHRP generates a pulse of GH. It does this through several mechanisms. One mechanism is the reduction of somatostatin release from your hypothalamus, this band are brilliant a reduction of somatostatin influence with the pituitary, still another is increased relieve GHRH from the brain and finally GHRPs act about the same pituitary cells (somatotrophs) just as GHRHs but utilize a different mechanism to improve cAMP formation which will further cause GH release from somatotroph stores.

GHRH also has a means of reciprocally reinforcing GHRPs action.

It's wise a synergistic GH release.

The GH isn't additive it can be synergistic. By that I mean:

If GHRH alone will result in a GH release valued at 2 and GHRP itself may cause a GH release worth 5

Together the GH just isn't 7 (5+2) as it happens to say 16!

A solid protocol

An excellent protocol would be to make use of a GHRP + a GHRH analog pre-bed (to compliment the nightime pulse) and when or twice the whole day.

For anti-aging, deep restful restorative sleep, the once through the night dosing 's all you need. With an adult aged 40+ it can be enough to bring back GH to youthful levels.

Except for bodybuilding or fatloss or injury repair multiple dosings could be effective.

The GHRH analog may be used at 100mcg so when high as you would like without difficulty.

The GHRP-6 can always be used at 100mcg w/o problems but a dose of 200mcg might be fine also.

Again desensitization is a thing to keep an eye on particularly with the highest doses of GHRP-2 and doses of Hexarelin.

So 100 - 200mcg of GHRP-6 + 100 - 500mcg+ of the GHRH analog taken together is going to be effective. This might be dosed repeatedly a day being successful.

A good approach is much more conservative at 100mcg of GHRP-6 + 100mcg of the GHRH analog dosed either once, twice, three to four times a day. When dosing several times per day at least 3 hours should separate the administrations.

The gap is once daily dosing pre-bed will give a youthful restorative volume of GH while multiple dosing as well as higher levels gives higher GH & IGF-1 levels when coupled with diet & exercise will bring about muscle gain & fatloss.

Dose w/o food

Administration should ideally be achieved on either an empty stomach or with only protein in the stomach. Fats & carbs blunt GH release. So administer the peptides and wait about Twenty or so minutes (forget about then 30 but truth be told then Fifteen minutes) to nibble on. AT that point the GH pulse has about hit the height and you may eat what you want.

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